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KMID : 0381019850180010029
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Korean Journal of Nutrition
1985 Volume.18 No. 1 p.29 ~ p.35
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Effect of Tocopherol Supplementation on HDL Subfraction and Lipoprotein Pattern in Rabbits Fed High Polyunsaturated Fatty Acids
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Abstract
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This study was designed to evaluate the effects of tocopherol supplementation on serum HDL2 and HDL3 subfraction and lipoprotein pattern of young rabbits fed the different levels of dietary polyunsaturated fatty acids.
White male rabbits with an average body weight of 90kg were assigned into 4 gorups : LP ( Low PUFA) ; HP ( High PUFA) ; LPT (Tocopheror added to LP) ; HPT ( Tocopherol added to HP) by feeding safflower oil or coconut oil at 10?/o( w/ w) in addition to thow diet with or without tocopherol for 4 weeks. HDLChol and HDL subfractions were determined by poly-anionic precipitation method, and the relative amount of lipoprotein by electrophoresis.
Serum total cholesterol and TG wer slightly lowered in the group of high PUFA diet and its effect was more in the case of tocopherol supplemented. HDLChol level was reduced in the high PUFA diet with or without tocopherol, but overall, HDLChoi level was not influenced by tocopherol addition and also no significant change in lipoprotein pattern when tocopherol added to the HP diet.
HDL2 level was increased in HPT group but not in LPT group when tocopherol was added to each HP and LP group, respectively. HDL3 levels of both LP and HP groups were reduced with tocopherol supplement, but the reduction was less in the high PUFA groups so that HDL2: HDL3 ratio of HP was rather close to that of LP, but it was increased when tocopherol supplemented to the HP diet. Therefore, high PUFA diet could improve the antiatherogenic factor when tocopherol supplemented.
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